SUN-398 LUPUS NEPHRITIS: EPIDEMIOLOGICAL, CLINICAL THERAPEUTIC CHARACTERISTICS AND OUTCOME

New Therapeutic Strategies in Lupus Nephritis

LUPUs nEPHrItIs - cLInIcaL and tHEraPEUtIcaL asPEcts

Received for publication: 25 Jul. 2006. Revised: 09 Mar. 2007. rEZUMat 3rd Ambulatory, Timisoara Clinical Municipal Hospital

Histological and clinical evolution of lupus nephritis.

In recent years, lupus nephritis has become the major complication and the most pressing problem in patients suffering from lupus erythematosus disseminatus. The clinical course of the disease was different 15 years ago, when Keith (1940) wrote that "renal insufficiency does not play an important role in causing death". At that time patients usually died of a "lupus crisis" or as a result of co...

Clinical significance of necrosis in lupus nephritis.

The significance of necrosis (karyorrhexis), among the most characteristic findings in lupus nephritis, was evaluated by studying the correlation between the existence of necrosis in renal biopsy specimens and laboratory findings. The subjects were 54 patients with diffuse proliferative lupus nephritis and 6 patients with focal proliferative lupus nephritis selected from 143 patients with lupus...

Chemokines and chemokine receptors as therapeutic targets in lupus nephritis.

Recruitment of leukocytes is a characteristic feature of tissue injury in systemic lupus erythematosus, including lupus nephritis. Locally secreted chemokines and their receptors are important mediators of leukocyte recruitment to the specific sites of immune complex injury, and contribute to renal inflammatory disease in the initiation and progression phase. Therefore, chemokines and chemokine...